Alpha-GPC has been demonstrated to enhance both mental and physical performance. Administration of alpha-GPC promotes learning and memory by increasing the release of the neurotransmitter acetylcholine. Alpha-GPC supplementation improves endurance and growth hormone secretion in athletes while preventing the decline in choline levels brought on by exercise. Although it has been demonstrated that caffeine improves mental clarity, intelligence, and physical performance, it also adds to a worried or anxious mood. The aim of this study was to evaluate the acute effects of Alpha-GPC supplementation on mood, cognitive function, and physiological performance in comparison to coffee or a placebo.